In the summer of 1493, Rodrigo Borgia, Alexander VI, has been pope for almost a year. Having played a crucial role in helping him ascend the throne of Saint Peter, Francesca, haunted by the shadows of her own past, is now charged with keeping him there. As court poisoner to the most notorious and dangerous family in Italy, this mistress of death faces a web of danger, intrigue, and deceit that threatens to extinguish the light of the Renaissance.
From the hidden crypts of 15th century Rome to its teeming streets alive with sensuality, obsession, and treachery, Francesca must battle the demons of her own dark nature to unravel a plot to destroy the Borgias, seize control of Christendom, and plunge the world into eternal darkness.