I'm fortunate that I haven't had to pick up my entire life, move somewhere else and start over. I have had to, very recently, basically start over my relationship with my only sister. We were on the outs for quite a while and not speaking to each other( alot of deep issues from the past). My mom has terminal cancer, and my relationship with my sister was just tearing her up, since we are the only 2 siblings left for each other.(My brother passed away 15 years ago at the age of 25 from brain cancer) Anyway, my sister and I sat down and talked for hours, cleared the air of our issues and have for the restarted our relationship and are finally getting along very well. This has also helped my mom find more peace.