The story's narrator, Raymond Smith, is based on Kerouac himself, and the poet-woodsman-Buddhist, Japhy Ryder, is a thinly disguised portrait of the poet Gary Synder. The book contains a number of other characters who are drawn from actual poets and writers. The plot unfolds when Smith, who is suffering spiritual conflicts amid the emptiness of middle-class American life, meets Ryder, whom he immediately recognizes as a spiritual model. The novel tells of the growth of their friendship and Smith's groping toward personal understanding. Much of the story occurs on the American West Coast.